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In the canonical pyroptotic pathway, pathogen- or danger-associated stimuli activate inflammasomes, which in turn activate caspase-1
Wang J, Ke T, Zhang X, Chen Y, Liu M, Chen J, Luo W
[6] Beyond pigmentary effects, the gray-market literature also describes nausea and facial flushing, spontaneous penile erection (priapism, an MC4R-mediated effect), and occasional systemic reactions such as rhabdomyolysis
It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin)
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